Ciclopirox in pregnancy and breastfeeding

Ciclopirox]]>

Risk Factor: BM
Class: Anti-infectives/ Antifungals

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References

Fetal Risk Summary

Ciclopirox is a synthetic antiinfective agent used topically for its antifungal properties. Very small amounts (1.3% of the dose with occlusive dressings) are absorbed systemically from the skin (1).

There was no evidence of teratogenic effects or other fetal harm in animals (mice, rats, rabbits, and monkeys) given doses of 10 times or more the topical human dose by various routes of administration (1).

No reports of its use in human pregnancy have been located. The manufacturer has no case reports of congenital abnormalities occurring after use of ciclopirox (C.K. Whitmore, personal communication, Hoechst-Roussel Pharmaceuticals, Inc., 1987).

Breast Feeding Summary

No reports describing the use of ciclopirox during lactation have been located. The very small amounts (1.3%) absorbed systemically with occlusive dressings probably indicates that infant exposure via the milk is negligible, if it occurs at all.

References

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  1. Product information. Loprox. MEDICIS, The Dermatology Company, 2000.

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