CICLOPIROX
Drugs in Pregnancy and Lactation.
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Name: CICLOPIROX
Class: Antifungal
Risk Factor: BM
Fetal Risk Summary
Ciclopirox is a synthetic antiinfective agent used topically for its antifungal properties. Very small amounts (1.3% of the dose with occlusive dressings) are absorbed systemically from the skin (1).
There was no evidence of teratogenic effects or other fetal harm in animals (mice, rats, rabbits, and monkeys) given doses of 10 times or more the topical human dose by various routes of administration (1).
No reports of its use in human pregnancy have been located. The manufacturer has no case reports of congenital abnormalities occurring after use of ciclopirox (C.K. Whitmore, personal communication, Hoechst-Roussel Pharmaceuticals, Inc., 1987).
Breast Feeding Summary
No reports describing the use of ciclopirox during lactation have been located. The very small amounts (1.3%) absorbed systemically with occlusive dressings probably indicates that infant exposure via the milk is negligible, if it occurs at all.
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