Cefixime
Risk Factor: BM
Class: ANTI-INFECTIVES
/ Cephalosporins
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Cefixime is an oral, semisynthetic cephalosporin antibiotic. Reproduction studies found no evidence in rats of impaired fertility or reproductive performance at doses up to 125 times the adult therapeutic dose or, in mice and rats, of teratogenicity at doses up to 400 times the human dose (1).
A 1998 noninterventional observational cohort study described the outcomes of pregnancies in women who had been prescribed one or more of 34 newly marketed drugs by general practitioners in England (2). Data were obtained by questionnaires sent to the prescribing physicians one month after the expected or possible date of delivery. In 831 (78%) of the pregnancies, a newly marketed drug was thought to have been taken during the 1st trimester with birth defects noted in 14 (2.5%) singleton births of the 557 newborns (10 sets of twins). In addition, two birth defects were observed in aborted fetuses. However, few of the aborted fetuses were examined. Cefixime was taken during the 1st trimester in 11 pregnancies. The outcomes of these pregnancies included two spontaneous abortions, one elective abortion, seven normal newborns (one premature), and one unknown outcome (2).
No other reports describing the use of cefixime in human pregnancy have been located. Cephalosporins are usually considered safe to use during pregnancy (see also other cephalosporins).
Breast Feeding Summary
No reports describing the use of cefixime during human lactation, or measuring the amount of the drug excreted in milk, have been located. Low concentrations of other cephalosporins have been measured, however, and the presence of cefixime in milk should be expected. Three potential problems exist for the nursing infant exposed to cefixime in milk: modification of bowel flora, direct effects on the infant, and interference with the interpretation of culture results if a fever workup is required. Although not specifically listing cefixime, the American Academy of Pediatrics classifies other cephalosporin antibiotics as compatible with breast feeding (3).
References
- Product information. Suprax. Lederle Laboratories, 1997.
- Wilton LV, Pearce GL, Martin RM, Mackay FJ, Mann RD. The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England. Br J Obstet Gynaecol 1998;105:8829.
-
Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:13750.
Questions and Answers
Does CEFIXIME (Surpax) kill Yersinia and Proteus Mirabillis bacteria?, I know that CEFIXIME (third Generations of Cephalosporins) could kill negative-grams bacteria, but I am not sure if this guy could kill YERSINIA and PROTEUS MIRABILIS. If could not, Do you guys know how to kill them off? Thank you very much.
Cefixime looks like it would be effective against P. mirabillis.
The literature lists activity against Y. enterocolitica, but doesn't mention Y. pestis.
For Y. pestis (the "plague"):
1) streptomycin
2) gentamycin
3) doxycycline
4) ciprofloxacin
5) chloramphenicol
Does taking antibiotics (cefixime) effect the mantoux test results ?,
If a person had a positive TB mantoux skin test it means the person has existing antibodies to the tuberculosis antigen meaning they either have TB or had it in the past.
The procedures works like this: a small amount of antigen is applied intradermally. The antibodies cross react with that antigen and form a red swelling. A test is read as positive if the bump is larger than 5 millimeters. The test is read 48 hours after the inital dose so a person may initially receive a reaction after the first few hours but it can subside 2 days later.
Antibiotics will not influence the test because the antigen is placed intradermally(just belw surface of the skin) and antibiotics taken orally will affect the body systemically(blood stream). Cefixime will not inhibit the formation of a positive result or interfere with it appearing.
IS THERE ANY SIDE EFFECTS BY USING CEFIXIME IN PREGNANCY?,
It is a 3 rd generation oral cephalosporin antibiotic, relatively safe when used during pregnancy. However the dosage, the duration of treatment and the indication for it's usage should be proper. Unless you are hypersensitive to cephalosporin/penicillin it should not be a problem, though there minor adverse reactions like bowel disturbances, abdominal cramps etc. It is always best to consult your physician before using it.
Cefixime with dose of 800 mg daily is that ok? with reffrence please..?, The doctor of my friend said to her to take 400mg capsule every 12 hours , the inclosed leaflet says that the dose is 400mg daily .. so what she can do ? is that ok ? where can I find more information?
As you suggest, cefixime, generic name for Suprax, is usually dosed at 400 mg once a day. The 800 mg dose is not usually dangerous, perhaps a little wasteful.
From http://www.rxlist.com/cgi/generic/cefixi...
"Adults: The recommended dose of SUPRAX is 400 mg daily. This may be given as a 400 mg tablet daily or as 200 mg tablet every 12 hours. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400 mg is recommended.
Children: The recommended dose is 8 mg/kg/day of the suspension. This may be administered as a single daily dose or may be given in two divided doses, as 4 mg/kg every 12 hours."
From http://www.rxlist.com/cgi/generic/cefixi...
"Adverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g (2000 mg) of SUPRAX did not differ from the profile seen in patients treated at the recommended doses."
General information (from http://health.msn.com/drugfinder/article...
Cefixime, is an antibiotic (fights bacteria in the body) in a class of drugs called cephalosporins used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections (also be used for other infections)
Other considerations:
There are no special restrictions on food, beverages, or activities during cefixime therapy unless otherwise directed by your doctor. Take cefixime with food or milk if it causes stomach upset.
Less serious side effects may occur such as mild nausea or diarrhea, or yeast infection of the mouth or vagina. Possible serious side effects of cefixime, though rare, include allergy (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; hives; or a rash), rash, redness, or itching; nausea, vomiting, or diarrhea; mucous or blood in the stool; or unusual bleeding or bruising. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
i whant khow about cefixime?,
it is an antibiotics, belongs to the group called cephalosporins. good luck
why is this drugs indicated to a patient with hydrocephalus with bronchopneumonia?, can u tell me why is it indicated:
1.Cotrimoxazole
2. Phenobarbital
3. Acetazolamide
4. Co-Amoxiclav
5. Valproic acid
6. Domperidone
7. Rifampicin
8. Cloxacillin
9. Cefixime
10. Heraclene
11. Salbutamol syrup
I'll be very basic and let you know what the drugs are for. I am not commenting if this regimen is appropriate or not for the patient, as obviously, I don't know the patient.
Cotrimoxazole (Bactrim), co-amoxyclav (Augmentin), rifampicin, cloxacillin, and cefixime are all ANTIBIOTICS. Phenobarbital, and valproic acid are ANTI-SEIZURE drugs. Acetazolamide is a DIURETIC, it gets rid of excess water in the body. Domperidone is typically used to control NAUSEA/VOMITING. Heraclene I'm not familiar with, but I think it's a vitamin or appetite stimulant. Salbutamol is usually for asthma to help people breathe more easily.
I wonder why you ask this. Is this the list of medications for someone you know with pneumonia and hydrocephalus and you're trying to figure out which drug is for what? If so, I would strongly suggest that you direct your questions to the doctor/s who prescribed the meds and let them explain it to you, instead of gathering information from a site like this where there is a big chance of you getting misinformed.
can anyone perscribe me gonorrhea medication?, can anyone perscribe me gonorrhea medication? for how long should i take it?
my doc game cipro for the treatment and later the cefixime ( 1 400 mg tablet for 10 days)... but im still having the infection back... pls guide me
Go to Drugstore.com
email==aboutrx@drugstore.com
Telephone==800 378 4786
They can call a doctor in your home country and get the necessary prescription, and mail it to you.
