Cefadroxil
Risk Factor: BM
Class: ANTI-INFECTIVES
/ Cephalosporins
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Cefadroxil is an oral, semisynthetic cephalosporin antibiotic. Reproduction studies in mice and rats found no evidence of impaired fertility or fetal harm at doses up to 11 times the human dose (1). Cephalosporins are usually considered safe to use during pregnancy (see other cephalosporins for published human experience).
At term, a 500-mg oral dose produced an average peak cord serum level of 4.6 g/mL at 2.5 hours (about 40% of maternal serum) (2). Amniotic fluid levels achieved a peak of 4.4 g/mL at 10 hours. No infant data were given.
In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 722 newborns had been exposed to cefadroxil during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 27 (3.7%) major birth defects were observed (30 expected). Specific data were available for six defect categories, including (observed/expected) 1/1 cardiovascular defects, 0/1 oral clefts, 0/0.5 spina bifida, 2/2 polydactyly, 2/1 limb reduction defects, and 1/2 hypospadias. These data do not support an association between the drug and congenital defects (see also Cefaclor, Cephalexin, and Cephradine for contrasting results).
Cefadroxil, 500 mg twice daily for 10 days following an IV dose of ceftazidime, was used in 12 women for the treatment of asymptomatic bacteruria during the 1st trimester (see also Ceftazidime) (3). No adverse effects of the treatment were observed.
Breast Feeding Summary
Cefadroxil is excreted into breast milk in low concentrations. Following a single 500-mg oral dose, peak milk levels of about 0.60.7 g/mL occurred at 56 hours (2). A 1-g oral dose given to six mothers produced peak milk levels averaging 1.83 g/mL (range 1.22.4 g/mL) at 67 hours (4). In this latter group, milk:plasma ratios at 1, 2, and 3 hours were 0.009, 0.011, and 0.019, respectively. Although these levels are low, three potential problems exist for the nursing infant: modification of bowel flora, direct effects on the infant, and interference with the interpretation of culture results if a fever workup is required. The American Academy of Pediatrics considers cefadroxil to be compatible with breast feeding (5).
References
- Product information. Duricef. Bristol-Myers Squibb Company, 1997.
- Takase Z, Shirafuji H, Uchida M. Experimental and clinical studies of cefadroxil in the treatment of infections in the field of obstetrics and gynecology. Chemotherapy (Tokyo) 1980;28(Suppl 2):42431.
- Nathorst-Boos J, Philipson A, Hedman A, Arvisson A. Renal elimination of ceftazidime during pregnancy. Am J Obstet Gynecol 1995;172:1636.
- Kafetzi D, Siafas C, Georgakopoulos P, Papdatos C. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand 1981;70:2858.
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Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:13750.
Questions and Answers
How long does it take cefadroxil to work?, I was diagnosed with tonsilitis and strep throat this morning and was put on cefadroxil (expensive as heck)
I've had my second does of it (per doctor's order) and there is not even a little difference. There is less pain, but i think that might be the vicodin talking. How long does it normally take to clear up?
Cefadroxil is normally active within 1 1/2 to 2 hours but it's not a painkiller, it's an antibiotic so you won't necessarily feel pain relief from it.
If your throat continues to be sore, take paracetemol.
Can any one tell me about generic cefadroxil's side effects?,
Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS). Dyspepsia, nausea and vomiting have been reported rarely. Diarrhea has also occurred.
Hypersensitivity
Allergies (in the form of rash, urticaria, angioedema, and pruritis) have been observed. These reactions usually subsided upon discontinuation of the drug. Anaphylaxis has also been reported.
Other
Other reactions have included hepatic dysfunction including cholestasis and elevations in serum transaminase, genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Agranulocytosis, thrombocytopenia, idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia have been rarely reported.
In addition to the adverse reactions listed above which have been observed in patients treated with cefadroxil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:
Toxic epidermal necrolysis, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs test, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated bilirubin, elevated LDH, eosinophilia, pancytopenia, neutropenia.
Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced (see DOSAGE AND ADMINISTRATION and OVERDOSAGE). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.
Might the medications fluconazole and cefadroxil ?, delay a period?
No! the fluconazol was given to you to get rid of the yeast caused by the imbalance of the PH in the normal flora for your vagina due to the bacterial infection for which you were prescribed the antibiotic cefadroxil. Neither of which will cause your period to be late
I took two pills of cefadroxil 500 by mistake together, will anything bad happen to me??, I took two pills of cefadroxil 500 by mistake together, will anything bad happen to me??
Cefodroxil is antibiotic, prescribed for mild to moderate infections. If u r reading this answer & feeling normal, relax nothing will happen now.
Cefadroxil or Amoxicillin for UTI?, Which antibiotic is more effective for a UTI in a 32 year old otherwise healthy (on no other medications) woman - Cefadroxil or Amoxicillin?
Either one will work. Amoxicillin is cheaper, but both work effectively.
can you get high or trip from cefadroxil?, no lectures
Yes, I think you probably can. Just like with any medicine, if you take enough it can have some "strange" affects on you. You probably wont get a really good trip like you would off of acid or anything, but it'd get you a little bit of something.
Why does my 5 month old have two red dots on either side of his mouth?, They are about the size of a dime. What could cause something like this. They are not dry skin or an alergic reaction. he also is taking cefadroxil and does not suck a binky
Cefadroxil side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
diarrhea that is watery or bloody;
severe blistering, peeling, and red skin rash;
fever, chills, sore throat, flu symptoms;
unusual bleeding or bruising;
seizure (black-out or convulsions); or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
