Cefaclor Risk Summary

Risk Factor: BM
Class: Anti-infectives / Cephalosporins

Fetal Risk Summary

Cefaclor is an oral, semisynthetic cephalosporin antibiotic. Reproduction studies in mice, rats, and ferrets found no evidence of impaired fertility or fetal harm at doses up to 12, 12, and 3 times, respectively, the human dose (1). Cephalosporins are usually considered safe to use during pregnancy (see other cephalosporins for published human experience).

In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 1,325 newborns had been exposed to the antibiotic during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 75 (5.7%) major birth defects were observed (56 expected). Specific data were available for six defect categories, including (observed/expected) 19/13 cardiovascular defects, 8/2 oral clefts, 1/0.7 spina bifida, 1/4 polydactyly, 2/2 limb reduction defects, and 3/3 hypospadias. The data for all defects, cardiovascular defects, and oral clefts are suggestive of an association between cefaclor and congenital defects, but other factors, such as the mother's disease, may be involved. However, similar findings were measured for another cephalosporin antibiotic with more than a thousand exposures (see Cephalexin). Positive results were also suggested for cephradine (339 exposures) but not for cefadroxil (722 exposures) (see Cephradine and Cefadroxil). In contrast, other antiinfectives with large cohorts (see Ampicillin, Amoxicillin, Penicillin G, Erythromycin, and Tetracycline) were not associated with congenital defects.

Breast Feeding Summary

Cefaclor is excreted into breast milk in low concentrations. Following a single 500-mg oral dose, average milk levels ranged from 0.160.21 g/mL during a 5-hour period (2). Only trace amounts of the antibiotic could be measured at 1 and 6 hours. Even though these levels are low, three potential problems exist for the nursing infant: modification of bowel flora, direct effects on the infant, and interference with the interpretation of culture results if a fever workup is required. Although not specifically listing cefaclor, the American Academy of Pediatrics classifies other cephalosporin antibiotics as compatible with breast feeding (3).

References

1. Product information. Ceclor. Eli Lilly and Company, 1997.
2. Takase Z. Clinical and laboratory studies of cefaclor in the field of obstetrics and gynecology. Chemotherapy (Tokyo) 1979;27(Suppl):668.
3. Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:13750.

Questions and Answers

Cefaclor .....................?, i was prescirbed cefaclor for tonsillitis yesterday

i took one without reading the leaflet thing in the packet

and then read the leaflet because i got really itchy and a bumpy rash on my face and neck

im not itchy anymore but the rash is still there ,

im allergic to penicillin and amoxacilin and eruthromicyn

it said i shouldn't have taken it

so i called the dr and he said that i should just keep taking it

i don't think i should keep taking though

does anybody know if what he said is right or weather i should ask another dr for different stuff or something

thanks

xx

People allergic to penicillin should take this medication with caution as they have an increased risk of being allergic to cephalosporin antibiotics.
the reason he told you to continue is because your not itchy anymore and probably he thinks it's not an allergic reaction. if it was an allergy it would continuue and get worse.

I just took 500mg of cefaclor and then accidentally took 500mg amoxicilin?, i took the amoxicilin like 1.5 hours after the cefaclor. is this ok?

yes just do not do it again

My husband recently finished a run of Cefaclor and now I have a yeast infection. Would Cefaclor have caused it,

no.

Is it okay to drink alcohol when taking the antibiotic Cefaclor?, And I am being antibiotic specific, please dont give me any "generally"s.

i wouldnt. drugs and alcohol r never meant to b mixed. it can cause major problems either short term or long term. its better to let the drugs do there job and u can have lots of time later on to have a drink or 2

What does the 'CD' abbreviation mean in Cefaclor-CD or Ceclor CD?,

curative dose (CD) which means the dose required to eliminate the symptoms of a disease or to correct the manifestations of a deficiency in the diet.

Can I use the the med Cefaclor(liquid) after the expiration date?, It expired 10-29

Nope. They're there for a reason.

The bigger question is why you have leftover antibiotic. You should always finish a course of antibiotics. If you have to stop it because of a bad reaction, why keep it around?

Is cefaclor an amphetamine or narcoticor or neither ?,

Cefaclor, or ceclor is an antibiotic. It is in the class of drugs known as Cephalosporins. It is used primarily for lung, urinary, skin and skin structure and ear infections.

There are any number of authoratative drug references on the web. I've posted some below.

can you take cefaclor antibiotic, while taking lexapro?,

As I know no but we should ask your doctor or physician . Thank you

The pill and antibiotics, does the antibiotic cefaclor - part of the Cephalosporins, interact with the pill?, I'm on the birth control pill femodette, i began to take it for the first time on the 1st day of my period meaning i am immediately covered for contraception, but for 5 days before i had been taking the antibiotics 'ceclor' which is from the group of Cephalosporins. It says to wait 7 days after taking antibiotics until you are covered again, but seen as i started it on the day after i finished my antibiotics should i wait longer? If i am immeditely protected as i started on the 1st day of my period, surely i should just wait the 7 days? please help?!

Yes, all antibiotics that I know of effect BC. You should always use a back up for that cycle of BC!!!!

Continue reading here: Clavulanate Potassium Risk Summary

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