CEFACLOR

Drugs in Pregnancy and Lactation.

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Name: CEFACLOR
Class: Antibiotic (Cephalosporin)
Risk Factor:    BM

Fetal Risk Summary

Cefaclor is an oral, semisynthetic cephalosporin antibiotic. Reproduction studies in mice, rats, and ferrets found no evidence of impaired fertility or fetal harm at doses up to 12, 12, and 3 times, respectively, the human dose (1). Cephalosporins are usually considered safe to use during pregnancy (see other cephalosporins for published human experience).

In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 1,325 newborns had been exposed to the antibiotic during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 75 (5.7%) major birth defects were observed (56 expected). Specific data were available for six defect categories, including (observed/expected) 19/13 cardiovascular defects, 8/2 oral clefts, 1/0.7 spina bifida, 1/4 polydactyly, 2/2 limb reduction defects, and 3/3 hypospadias. The data for all defects, cardiovascular defects, and oral clefts are suggestive of an association between cefaclor and congenital defects, but other factors, such as the mother's disease, may be involved. However, similar findings were measured for another cephalosporin antibiotic with more than a thousand exposures (see Cephalexin). Positive results were also suggested for cephradine (339 exposures) but not for cefadroxil (722 exposures) (see Cephradine and Cefadroxil). In contrast, other antiinfectives with large cohorts (see Ampicillin, Amoxicillin, Penicillin G, Erythromycin, and Tetracycline) were not associated with congenital defects.

Breast Feeding Summary

Cefaclor is excreted into breast milk in low concentrations. Following a single 500-mg oral dose, average milk levels ranged from 0.16–0.21 µg/mL during a 5-hour period (2). Only trace amounts of the antibiotic could be measured at 1 and 6 hours. Even though these levels are low, three potential problems exist for the nursing infant: modification of bowel flora, direct effects on the infant, and interference with the interpretation of culture results if a fever workup is required. Although not specifically listing cefaclor, the American Academy of Pediatrics classifies other cephalosporin antibiotics as compatible with breast feeding (3).

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References

  1. Product information. Ceclor. Eli Lilly and Company, 1997.
  2. Takase Z. Clinical and laboratory studies of cefaclor in the field of obstetrics and gynecology. Chemotherapy (Tokyo) 1979;27(Suppl):668.
  3. Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:137–50.

Index

Q&A about Cefaclor

xstalkrx
I just took 500mg of cefaclor and then accidentally took 500mg amoxicilin?
i took the amoxicilin like 1.5 hours after the cefaclor. is this ok?
pearl_ho...
yes just do not do it again
rebekahm...
My husband recently finished a run of Cefaclor and now I have a yeast infection. Would Cefaclor have caused it
drankurb...
no.
Kiria
Is it okay to drink alcohol when taking the antibiotic Cefaclor?
And I am being antibiotic specific, please dont give me any "generally"s.
fuzzycak...
i wouldnt. drugs and alcohol r never meant to b mixed. it can cause major problems either short term or long term. its better to let the drugs do there job and u can have lots of time later on to have a drink or 2
camchain
Is cefaclor an amphetamine or narcoticor or neither ?
matt the librarian
Cefaclor, or ceclor is an antibiotic. It is in the class of drugs known as Cephalosporins. It is used primarily for lung, urinary, skin and skin structure and ear infections.

There are any number of authoratative drug references on the web. I've posted some below.
geneva s
can you take cefaclor antibiotic, while taking lexapro?
sucreeje...
There is no contraindications between the 2. And if there was, your doctor or pharmacist should have already informed you of it.
Jessica
The pill and antibiotics, does the antibiotic cefaclor - part of the Cephalosporins, interact with the pill?
I'm on the birth control pill femodette, i began to take it for the first time on the 1st day of my period meaning i am immediately covered for contraception, but for 5 days before i had been taking the antibiotics 'ceclor' which is from the group of Cephalosporins. It says to wait 7 days after taking antibiotics until you are covered again, but seen as i started it on the day after i finished my antibiotics should i wait longer? If i am immeditely protected as i started on the 1st day of my period, surely i should just wait the 7 days? please help?!
ღ♥By the way♥ღ
Yes, all antibiotics that I know of effect BC. You should always use a back up for that cycle of BC!!!!

USE CONDOMS UNTIL YOU HAVE STARTED A NEW PACK!!!

Be careful

Ash
grandma tracy
does cefaclor cause you to retain water?
Rachel
It shouldn't, but these drugs can be harmful to your liver and kidneys and can produce this!

You should contact the doctor that gave this drug to you!
mums
what's the use of cefaclor sustain -realeased tablets?
this drugs was prescribed by a doctor for itches around my neck
cindy p
cefaclor is an antibiotic...you should ask the doc why he prescribed this
teredenz
cefaclor for infants?
do i need to stop giving my 11 month old baby cefaclor(suspension drops) if he continuous developing painful diaper rashes and rashes at the back(like sunburned skin) --- the medicine was prescribed for asthmatic bronchitis
shannonl...
If your child is having alergic reactions then you need to schedule a visit with the dr and quit giving the meds. They will probibly want to see you right away. Also you need to watch for swelling in the lips, and eyes also weezing and swelling of the throat as they are signs of a severe allergic reaction and require you to go to the emergency room. Call your Doctor right away and let them know what is going on, your child should not be having that kind of reaction to a medication that is supposed to be helping them.