BUTAPERAZINE

Fetal Risk Summary

Butaperazine is a piperazine phenothiazine in the same group as prochlorperazine (see Prochlorperazine). The phenothiazines readily cross the placenta (1). No specific information on the use of butaperazine in pregnancy has been located. Although occasional reports have attempted to link various phenothiazine compounds with congenital malformations, the bulk of the evidence indicates that these drugs are safe for the mother and fetus (see also Chlorpromazine).

Breast Feeding Summary

No reports describing the use of butaperazine during human lactation have been located. Because other phenothiazines appear in human milk (e.g., chlorpromazine), excretion of butaperazine should be expected. Sedation is a potential effect in the nursing infant.

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