Bethanechol
Risk Factor: CM
Class: AUTONOMICS
/ Parasympathomimetics (Cholinergics)
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Bethanechol is indicated for the treatment of nonobstructive urinary retention and neurogenic atony of the urinary bladder with retention. Reproduction studies in animals have not been conducted (1).
The use of bethanechol in human pregnancy has been reported, but too little data are available to analyze (2).
Breast Feeding Summary
Specific data on the excretion of bethanechol into breast milk are lacking. The molecular weight (about 197) is low enough, however, that excretion into milk should be expected. One author cautioned that mothers receiving regular therapy with this drug should not breast-feed (3). Abdominal pain and diarrhea have been reported in a nursing infant exposed to bethanechol in milk (4).
References
- Product information. Urecholine. Merck, 2000.
- Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA:Publishing Sciences Group, 1977:34556.
- Platzker ACD, Lew CD, Stewart D. Drug 9administration9 via breast milk. Hosp Pract 1980;15:11122.
-
Shore MF. Drugs can be dangerous during pregnancy and lactations. Can Pharmaceut J 1970;103:358. As cited in: Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human breast milk. Pediatrics 1983;72:37583.
Questions and Answers
Why can't bethanechol be admistered through IV but atropine can?,
Route of administration will be due to many factors:
1.efficacy- meaning how quickly or efficiently the drug works.
2.type- inhaled vs. subcutaneously vs. sublingual vs. intravenous vs. intramuscular.
3. molecular size- large vs. small. (inhaled would be a small molecule and IM a large molecule size.)
4.purpose- fast administration for life-saving, or slow administration for types of treatment.
Pharmacology has specific functions listed, and we Medical professionals must be aware in order to treat properly.
Does anyone know the safest Pro-Motility agent (such as bethanechol, reglan, propulsid) to give a infant for s, My daughter has severe acid reflux. Anyone know the safest medication out of the ones listed to give her. My doctor wants me to give her Reglan but I've heard a lot of bad stuff about it.
Severe reflux and he's checked the phyloric sphinctor for growth abnormalities and has reccomended Reglan? Then i'd listen to your doc. If you have questions about any drugs see a pharmacyst, they are especially knowledgable in this area and hugely under utilized.
