Beclomethasone
Risk Factor: CM
Class: Respiratory drugs
/ Corticosteroids (inhaled)
Contents of this page:
Fetal Risk Summary
Beclomethasone dipropionate is given by inhalation for the chronic treatment of bronchial asthma in patients requiring corticosteroid therapy for the control of symptoms. It is also available for intranasal use and, outside of the United States, for topical application.
Beclomethasone was embryocidal (increased fetal resorption) and teratogenic when administered by SC injection to mice and rabbits at approximately 10 times the human dose (1,2). Congenital malformations observed included cleft palate, agnathia, microstomia, absence of the tongue, delayed ossification, and agenesis of the thymus. Similar toxic effects in both species were observed with SC injections that were approximately one-half the maximum recommended adult daily inhalation dose on a mg/m2 basis (3). In the rat, no embryo or fetal harm was found with inhaled (at 10 times the human dose) or oral (at 1,000 times the human dose) beclomethasone (1,2).
No human reports associating the use of beclomethasone with human congenital anomalies have been found. A 1975 report briefly mentioned seven healthy babies born from mothers who had used beclomethasone aerosol for over 6 months (4). In another report, beclomethasone was used during 45 pregnancies in 40 women (5). Dosage ranged between 4 and 16 inhalations/day (mean 9.5), with each inhalation delivering 42mg of drug. Three of the 33 prospectively studied pregnancies ended in abortion that was not thought to be caused by the maternal asthma. Forty-three living infants resulted from the remaining 42 pregnancies. Six infants had low birth weights, including two of the three premature newborns (less than 37 weeks' gestation). There was no evidence of neonatal adrenal insufficiency. One full-term infant had cardiac malformations (double ventricular septal defect, patent ductus arteriosus, and subaortic stenosis). However, the mother's asthma was also treated with prednisone, theophylline, and epinephrine. In addition, she had schizophrenia and diabetes mellitus for which she took fluphenazine and insulin. Cardiac malformations are known to occur with diabetes mellitus (see Insulin).
In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 395 newborns had been exposed to beclomethasone during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 16 (4.1%) major birth defects were observed (16 expected). Specific information was not available on the defects, but no anomalies were observed in six categories (cardiovascular defects, oral clefts, spina bifida, polydactyly, limb reduction defects, and hypospadias). These data do not support an association between the drug and congenital defects.
Breast Feeding Summary
It is not known whether beclomethasone is excreted into breast milk. Other corticosteroids are excreted into milk in low concentrations (see Prednisone) and the passage of beclomethasone into milk should be expected. One report has been located that notes three cases of maternal beclomethasone use during breast feeding (4). Effects on the nursing infants were not mentioned.
References
- Product information. Beconase. Glaxo Wellcome, 2000.
- Product information. Vancenase; Vanceril. Schering, 2000.
- Product information. Beclovent. Glaxo Wellcome, 2000.
- Brown HM, Storey G. Treatment of allergy of the respiratory tract with beclomethasone dipropionate steroid aerosol. Postgrad Med J 1975;51(Suppl 4):5964.
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Greenberger PA, Patterson R. Beclomethasone dipropionate for severe asthma during pregnancy. Ann Intern Med 1983;98:47880.
Questions and Answers
Does the drug salbutamol interact with beclomethasone?, I take 2 puffs of 100mg salbutamol when required and 1 puff of 200mg when required. I've heard it is possible to get lymphoma when taking these drugs in combination, is this true?
no Someone is pulling your leg.
The dose of beclomethasone inhalant is 200 mcg twice a day. The commercial inhaler delivers 50 mcg per ?, inhalation and contains 200 inhalations. How many inhalers should be dispensed to a patient if a 60-day supply is prescribed?
IF you divide the daily total (400 mcg) by the amount per inhalation (50mcg) that gives you the total squirts per day(8). When you multiply it by 60 days you get 60*8 = 480 inhalations needed during that time.
If each inhaler does 200 inhalations and you need 480, divide the 480 by 200 and round it up to the next integer. That means 480/300 = 2.4 so you need 3 of them for 60 days.
Pregnancy and using Beclomethasone Dipropionate?, I am 7 weeks pregnant. I was told I am not allowed using any nasal sprays for my sinusitis. Or if I have to, it should be just for a couple of days. Now I am desperate, I can't breath without my Alanase (Beclomethasone Dipropionate) nasal spray, my nose is completely blocked! I can't sleep, it was my bible...
I've tried Otrivin (Xylometazoline hydrochloride) which helps unblocked my nose too, but again....I am not allowed to use it more than 5 days. What about the rest of the 7 months pregnancy I have?? How can I live without nasal spray?? I am so nervous, I breathe on my mouth all the time..
I have found a lot of relief by using those breath right strips and they even have them with menthol. You shouldn't have any trouble just using a saline spray along with some benadryl. Sounds like you have become dependent on the nasal sprays now, but I always have more trouble breathing when pregnant. again, the best thing for me was the breath right stuff. Good luck
asking for a trial about fluticasone vs beclomethasone (efficacy,safety,..)?,
Fluticasone has been shown to be as effective or more effective than beclomethasone, with fewere systemic effects, since fluticasone is less absorbed systemically. I don't have the particular literature citation readily available, but you can search for it on PubMed and you will find it there.
Why does sweat stain my white t-shirts pink?, Oops, I did not mean to close that!
When I have a hard jog I sweat a lot. My white t-shirt is soaked. When I take it out of the linen basket 3 days later to wash it, it is covered in bright pink blotches!
Things that may be relevant:
This doesn't always happen.
The pink washes out with a bio-soak and a hot wash.
I use non-bio liquitabs and an easy-iron conditioner.
I use a 'no-white marks' deodorant.
I take aciclovir for an eye condition; cetirizine for hay fever; salbutamol and beclomethasone for asthma.
I often drink white wine the night before so there is probably alcohol in my sweat.
I often eat spicy foods. The night before the last time, I ate spaghetti bolognese with some added chilli. I use sweeteners and lo-salt.
This has only been happening since I bought a new simple reed linen basket with a full white linen lining. The t-shirt doesn't touch the basket, or anything red or pin
It is your body chemistry interacting with the deoderant and fiber content of the fabric. What you consume, whether it be food or medication, and use topically (i.e. deoderant) contributes to your individual body chemistry which will then reacts not only to the fabric, but anything it also contains (detergents, fabric softeners, etc.) You should consider yourself lucky that a bio-soak removes the stain, for some people more extensive effort is required.
why did my doctor priscribe,for me a lotion called Tim-B,to apply on my hair,?, BECLOMETHASONE DIPROPIONATE WITH CLOTRIMAZOLE LOTION,
ITS COMPOSITION IS BECLOMETHASONE
DIPROPIONATE I.P. 0.025%
CLOTRIMAZOLE I.P 1%
NON AQUEOUS BASE QS.
CAN U HELP ME WHAT IS IT FOR
What hair you are talkin bout?i mean if it's about the hair on your head...i dunno nothing about it........
why do i get the shakes after?, i have took my inharlers i shake really bad my legs and hand and feel light headed. some time i have to wait after i took them before i drive or i go all funny. thanks buy the way am on the salamol cfc-free and beclomethasone diproionate thanks. i take them twice in the mornig and night and during the day if needed. am quite a bad astmah
Because of the sudden rush of oxygen your brain gets directly after a period of being deprived... as in an asthma attack that prompted you to take it in the first place.
All of your air ways open up and your brain gets flooded all at once with a blast of oxygen and blood pressure.
It mimics the effects of speed or an amphetamine.
I have had strep throat numerous times in the last 3 years - what can I do?, I have been to three Ear Nose & Throat specialists - the only treatment I have received is Beclomethasone... which I take every day three times per day.
I have strep now (or an EXTREMELY SORE THROAT) for the third time since the beginning of the year... I have has it at least 10 times on the last 3 years...
I am at a loss... I am a singer and this is a CURSE!!!
HELP!!!!
my mother is the same way. she constantly has strep. she is older, so tonsil surgury is dangerous and she doesn't want to have it. Her doctor said if you have strep over 3 times in 3 years, you should have them removed. My step-dad has his removed for the same problem, and one tonsil actually grew back!!! ugh! I've had strep, and I feel your pain!!! I hope you find something that works soon!
... i don't recommend trying this without asking your doctor:::: but, the last time I had strept, I did not go to the doctor. I decided to let it ride out it's course. I got very sick, and it took longer to go away, but it eventually did, and I haven't had it since (2 years ago). if that built up my immunity, I don't know. but it's a thought. HOWEVER, that said, my body had no energy to fight off anything after the strept and I got an extremely painful canker sore (couldn't open my mouth at all), and I broke out in hives. So there's definitely a price to pay!!
good luck!
For female asthmatics: do you get "premenstrual asthma"?, Actually, that's not accurate; it makes it sound like the asthma only occurs before one's period does. *chuckle*
What I mean is, if you already are a person with asthma, do you ever have an increase in symptoms a few days before your period? This happens to me every few months: I have a slight chest tightness on-and-off (especially upon waking up), and I get slightly "winded" doing things that normally wouldn't make me out of breath.
When it happens, my doctor gave me the green light to double my daily dose of QVAR (beclomethasone dipropionate), an inhaled steroid.
I'm pleased to say I've found a surprising amount of data online that supports the existence of premenstrual asthma flare-ups in some women (a hormone connection, of course!) However, I've never actually known anyone it happens to. So, I'm asking the ladies here. :)
Does this happen to you? If so, what symptoms? Also, if you don't mind telling me, what is your age? (This never happened when I was younger).
yes!! ok, i'm 18 and my first (and worst) asthma attack was 2 days before my first period started. also, i'm on the pill and i notice that if i'm late starting a pack, my asthma really gets alot worse.
