AZTREONAM
Drugs in Pregnancy and Lactation.
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Name: AZTREONAM
Class: Antibiotic
Risk Factor: BM
Fetal Risk Summary
Aztreonam is a synthetic, monocyclic b-lactam antibiotic that is structurally different from other b-lactam antibiotics, such as the penicillins and cephalosporins. Administration of high IV doses of the drug to pregnant rats (15 times the maximum recommended human dose [MRHD] and rabbits (5 times the MRHD) did not produce embryotoxic, fetotoxic, or teratogenic effects (1,2,3,4 and 5).
Single 1-g IV doses of aztreonam administered 2 to 8 hours before elective termination produced detectable concentrations of the antibiotic in fetal serum and amniotic fluid (6). No reports describing the therapeutic use of the antibiotic in human pregnancy have been located.
Breast Feeding Summary
Aztreonam is excreted into breast milk (7). Twelve lactating women received a single 1-g dose of the antibiotic either by IM injection (N=6) or by the IV route (N=6). Infants were not allowed to breast-feed during the study. Milk and serum samples were collected at scheduled intervals for 8 hours after the dose. In the IM group, the mean peak milk concentration was estimated to be 0.3 µg/mL, corresponding to a milk:serum ratio of 0.007. Similar calculations for the IV group yielded a peak value of 0.2 µg/mL and a ratio of 0.002. The low milk concentrations measured in the study were compatible with the acidic nature of the drug and its very low lipid solubility (7). These data, combined with the poor oral absorption of the antibiotic, indicate that direct systemic effects from the antibiotic in nursing infants are unlikely (7). The American Academy of Pediatrics considers aztreonam to be compatible with breast feeding (8).
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References
- Furuhashi T, Kato I, Igarashi Y, Nakayoshi H. Toxicity study of azthreonam: fertility study in rats. Chemotherapy 1985;33:190-202. As cited in Shepard TH. Catalog of Teratogenic Agents. 6th ed. Baltimore, MD:Johns Hopkins University Press, 1989:66.
- Furuhashi T, Ushida K, Sato K, Nakayoshi H. Toxicity study on azthreonam: Teratology study in rats. Chemotherapy 1985;33:203-18. As cited in Shepard TH. Catalog of Teratogenic Agents. 6th ed. Baltimore, MD:Johns Hopkins University Press, 1989:66.
- Furuhashi T, Ushida K, Kakei A, Nakayoshi H. Toxicity study on azthreonam: Perinatal and postnatal study in rats. Chemotherapy 1985;33:219-31. As cited in Shepard TH. Catalog of Teratogenic Agents. 6th ed. Baltimore, MD:Johns Hopkins University Press, 1989:66.
- Singhvi SM, Ita CE, Shaw JM, Keim GR, Migdalof BH. Distribution of aztreonam into fetuses and milk of rats. Antimicrob Agents Chemother 1984;26:132–5.
- Product information. Azactam. E. R. Squibb & Sons, 1994.
- Hayashi R, Devlin RG, Frantz M, Stern M. Concentration of aztreonam in body fluids in mid-pregnancy (abstract). Clin Pharmacol Ther 1984;35:246.
- Fleiss PM, Richwald GA, Gordon J, Stern M, Frantz M, Devlin RG. Aztreonam in human serum and breast milk. Br J Clin Pharmacol 1985;19:509–11.
- Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:137–50.
Q&A about Aztreonam
why do i get a unpleasant taste from my IV drugs?
my drug is 'AZTREONAM' and when it's injected i get a most unplesant taste in my mouth? why is this? how do i get this taste in my mouth so quickly?
my drug is 'AZTREONAM' and when it's injected i get a most unplesant taste in my mouth? why is this? how do i get this taste in my mouth so quickly?
I don't know the mechanism of this side-effect, but it is recognised as a side-effect of this drug. As the drug is given IV it gets into your system straight away. If, for example, a component of the drug gets from the bloodstream into the saliva very quickly, that would be one way. I wouldn't expect you to be on this treatment long-term, so try having something to eat or drink during/after the injection. If you can't bear this side-effect, tell the person treating you, but they'll probably tell you that this is the best drug for your condition and they can't change it. It's probably not much consolation, but there are much worse side-effects out there! Get well soon.
help me!! overcome pseudomonas virus?
My aunt is in a critical health situation. She is in coma since 2 months.
She has been affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
It seems that in Australia, Doctor Cocks has discovered a new possible way to defeat it, from the breast milk of wallaby. Do you know smt about it?
My aunt is in a critical health situation. She is in coma since 2 months.
She has been affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
It seems that in Australia, Doctor Cocks has discovered a new possible way to defeat it, from the breast milk of wallaby. Do you know smt about it?
First off, Pseudomonas is a bacteria, not a virus. Those antibiotics you listed are BAD choices to treat pseudomonas. I assume the infection is in her blood. She need tobramycin immediately. It is an IV based antibiotic. It is rare for Pseudo to be resistant to that. Tobramycin is the best choice, but a fluoroquinolone is another option. Examples of those include ciprofloxacin and levofloxacin. I still think tobra is the way to go...hopefully that is available to you in Italy.
Please help me! Overcome "pseudomonas"..?
My uncle is in a critical health situation.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
grazie di cuore.
My uncle is in a critical health situation.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
grazie di cuore.
It is a gram-negative bacteria, so penicillin won't work.
In the US, we might try some of the following:
piperacillin (Tazocin or Zosyn)
imipenem
tobramycin (Nebcin or Tobi)
ciprofloxacin (Cipro--which is also used to treat anthrax)
In the US, we might try some of the following:
piperacillin (Tazocin or Zosyn)
imipenem
tobramycin (Nebcin or Tobi)
ciprofloxacin (Cipro--which is also used to treat anthrax)
help me!! overcome pseudomonas aeruginosa?
My aunt is in a critical health situation. She is in coma since 2 months.
She has been affected by a strong bacteria, called "pseudomonas aeruginosa"
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM ).
The antibiogram shows that it resistant to all of antibiotics they tried.
Have you ever heard about Dr.Cocks and his discover about a cure from the breast milk of wallaby??
What to do??
Please..
My aunt is in a critical health situation. She is in coma since 2 months.
She has been affected by a strong bacteria, called "pseudomonas aeruginosa"
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM ).
The antibiogram shows that it resistant to all of antibiotics they tried.
Have you ever heard about Dr.Cocks and his discover about a cure from the breast milk of wallaby??
What to do??
Please..
P.aeruginosa has natural resistance to many antibiotics, including all penicillins except ticarcillin (13% resistance in Australia) and piperacillin (9% resistance in Australia), all cephalosporins except ceftazidime (10% resistance in Australia), cefipime and cefpirome, and trimethoprim, cotrimoxazole and tetracyclines. Gentamicin (17% resistance in Australia) and tobramycin (8% resistance in Australia) remain the favoured agents for hospital use but oral norfloxacin (UTI's only) and ciprofloxacin are most widely used in outpatients. Resistance to the latter two agents is now 37-38% in the USA but 8-13% in Australia. Imipenem is occasionally used in hospitals (17% resistance in Australia).
Colistin and neomycin are sometimes used topically and colistin is rarely used systemically as a drug of last resort.
Colistin and neomycin are sometimes used topically and colistin is rarely used systemically as a drug of last resort.
help me!overcome pseudomonas aeruginosa..?
My mumis in a critical health situation. She is in coma since 2 months.
She has been affected by a strong bacteria, called "pseudomonas aeruginosa"
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM ).
The antibiogram shows that it resistant to all of antibiotics they tried.
Have you ever heard about Dr.Cocks and his discover about a cure from the breast milk of wallaby??
What to do??
Please..
My mumis in a critical health situation. She is in coma since 2 months.
She has been affected by a strong bacteria, called "pseudomonas aeruginosa"
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM ).
The antibiogram shows that it resistant to all of antibiotics they tried.
Have you ever heard about Dr.Cocks and his discover about a cure from the breast milk of wallaby??
What to do??
Please..
Only a few antibiotics are effective against Pseudomonas, including fluoroquinolones, gentamicin and imipenem, and even these antibiotics are not effective against all strains.
It seems that some strains of pseudomonas are resistent to all antibiotics. Especially if the patient has cystic fibrosis.
I hope this helps. Good luck!
It seems that some strains of pseudomonas are resistent to all antibiotics. Especially if the patient has cystic fibrosis.
I hope this helps. Good luck!
Please HELP!!! overcome pseudomonas...?
My uncle is in a critical health situation.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
grazie di cuore.
My uncle is in a critical health situation.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
grazie di cuore.
I do not know what antibiotics you have in Italy but none of the names you write are ones we use here in the US. He needs Tobramycin, Gentamycin, Zosyn, and those are all IV antibiotics that need close watching of his kidney function labs as he gets them. IF he is immuno-compromised from other chronic illness, he is in a bad situation. I pray for him and that you can understand what I am writing to you.
My husband is in ICU with pneumonia?
He was admitted Friday night with a WBC of 16.5. They started him on vancomycin and aztreonam {not sure if I spelled those right}. That makes almost 72 hours of antibiotics when they took another blood test this afternoon. Now his WBC is 32,000 and he is in excruciating pain on his right upper side. They have him on so many heavy pain meds he is completely out of it. This is his third bout of pneumonia since January and no one can figure out what is wrong with him. I don't know where else to turn, how worried should I be? He is almost 52 years old.
He was admitted Friday night with a WBC of 16.5. They started him on vancomycin and aztreonam {not sure if I spelled those right}. That makes almost 72 hours of antibiotics when they took another blood test this afternoon. Now his WBC is 32,000 and he is in excruciating pain on his right upper side. They have him on so many heavy pain meds he is completely out of it. This is his third bout of pneumonia since January and no one can figure out what is wrong with him. I don't know where else to turn, how worried should I be? He is almost 52 years old.
A high WBC is taken to be "bad" because it shows there is in infection in the body. But it is actually good, because it shows the body's natural defences are in good working order. The white blood cells multiply to attack the invading organism that is causing the infection.
They have probably taken samples from his lungs, to test which anti-biotics are the most effective against whatever he has.
Now he has had the same problem so often, I am sure when he is a bit better they will do a full investigation into what is causing it to recur. One possibility is that earlier treatments were not continued long enough, leaving a few resistant bacteria to mulitply again.
They are not going to start doing biospies and other tests until he is better, as the first priority is to get him healthy again. Then they can look for preventing the problem from recurring.
He could also have an underlying other lung problem, such as mild emphysema, which is making the lungs more susceptible to infections.
It is normal to be worried when your husband is so sick. But he's getting expert care in a good modern hospital, so he will get better. The doctors there know a lot more about what other things to look for, than we can guess at from looking up websites. Don't let anyone panic you based on this.
They have probably taken samples from his lungs, to test which anti-biotics are the most effective against whatever he has.
Now he has had the same problem so often, I am sure when he is a bit better they will do a full investigation into what is causing it to recur. One possibility is that earlier treatments were not continued long enough, leaving a few resistant bacteria to mulitply again.
They are not going to start doing biospies and other tests until he is better, as the first priority is to get him healthy again. Then they can look for preventing the problem from recurring.
He could also have an underlying other lung problem, such as mild emphysema, which is making the lungs more susceptible to infections.
It is normal to be worried when your husband is so sick. But he's getting expert care in a good modern hospital, so he will get better. The doctors there know a lot more about what other things to look for, than we can guess at from looking up websites. Don't let anyone panic you based on this.
Help me!! overcome pseudomonas. AGG01?
My auntis in a critical health situation. She is in coma since 2 months.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
It seems that in Australia, Doctor Cocks has discovered a new possible way to defeat it, from the breast milk of wallaby. Do you know smt about it?
My auntis in a critical health situation. She is in coma since 2 months.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
It seems that in Australia, Doctor Cocks has discovered a new possible way to defeat it, from the breast milk of wallaby. Do you know smt about it?
booooooooooooooooooooooooo???im don't speck english.....im sorry my brothers......
Please,Help me!! overcome bacteria..?
My aunt is in a critical health situation. She is in coma since 2 months.
She has been affected by a strong bacteria, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
It seems that in Australia, Doctor Cocks has discovered a new possible way to defeat it, from the breast milk of wallaby. Do you know smt about it?
My aunt is in a critical health situation. She is in coma since 2 months.
She has been affected by a strong bacteria, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
It seems that in Australia, Doctor Cocks has discovered a new possible way to defeat it, from the breast milk of wallaby. Do you know smt about it?
IT really depends on the type of psuedomonas that she has...and the strand. Every bacteria is different to what it is sensitive to regarding antibiotic treatment. After IDing a bacteria...labs will do a sensitivity to see what antibiotics and at what strengths will stop growth. Also...is she immunosuppressed? This could be why she can't get rid of it also. If her immune system isn't aiding the antibiotics...the infection could continue.
PLEASE HELP ME! Overcome Pseudomonas..?
My mam is in a critical health situation.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
grazie di cuore.
My mam is in a critical health situation.
She has affected by a strong virus, called "pseudomonas".
Every italian antibiotic failed till now (TENACID, PRIMBCATIM, AZTREONAM e IMIPEM )
So please, please, just ask to a doctor if know one, maybe it is much less dangerous right there and the solution it s just a stupid pill that we don't have.
grazie di cuore.
Try below for expert advice and the best of luck!
http://www.mayoclinic.com/
or
http://www.healthline.com/
or
http://www.medicinenet.com/script/main/h...
or
http://www.netdoctor.co.uk/index.shtml
or
http://www.answers.com/answers.com?cat=b...
http://www.mayoclinic.com/
or
http://www.healthline.com/
or
http://www.medicinenet.com/script/main/h...
or
http://www.netdoctor.co.uk/index.shtml
or
http://www.answers.com/answers.com?cat=b...
