ANTIPYRINE
Drugs in Pregnancy and Lactation.
"Official medicines" is the best online drugstore.World’s leading meds delivered to your door – and you don’t even need a prescription! Only certified, first class drugs on offer! Buy more and spend less with our great discount system. |
Name: ANTIPYRINE
Class: Analgesic/Antipyretic
Risk Factor: C
Fetal Risk Summary
Because of its rare association with hemolytic anemia and agranulocytosis (1), antipyrine (phenazone), a prostaglandin synthesis inhibitor, is no longer available as a single agent. However, the drug is still available in some topical eardrops and in the prodrug, dichloralphenazone (see also Dichloralphenazone). This latter agent, a combination of chloral hydrate and antipyrine, is a component, along with isometheptene and acetaminophen, of several proprietary mixtures commonly used for tension and vascular (migraine) headaches (see also Isometheptene and Acetaminophen).
Although animal reproductive studies involving antipyrine have not been located, the drug has been used extensively in investigations of fetal metabolism in pregnant sheep as reviewed in a 1993 Reference (2). This latter investigation found that antipyrine did not affect umbilical metabolism, but did alter metabolism and blood flow distribution in the fetal lamb (2).
Eight cases of antipyrine exposure (presumably oral), among 27 women using a miscellaneous group of non-narcotic analgesics during the 1st trimester, were reported by the Collaborative Perinatal Project (3). From the 27 mother-child pairs, one infant had a congenital malformation (SRR 0.46), but the specific agent the mother had taken was not identified.
In a double-blind, randomized study of neonatal jaundice prophylaxis, either antipyrine (N=24), 300 mg/day, or placebo (N=24) was given from the 38th week of gestation until delivery (4). The average duration of treatment in both groups was 15.5 days. The mean bilirubin concentration in the infants 4 days after birth was 62.6 µmol/L in those exposed to antipyrine compared with 111.5 µmol/L in the placebo group (p<0.005). The authors attributed the decrease in bilirubin to the induction of glucuronyl transferase in the fetal liver, a known effect of antipyrine (4). No adverse effects in the newborns were observed.
Breast Feeding Summary
Antipyrine (phenazone), a nonelectrolyte with a molecular weight less than 200, freely diffuses into the aqueous phase of milk with a milk:plasma ratio of approximately 1.0 (5,6). No reports of its use during lactation have been located.
"Official medicines" is the best online drugstore.World’s leading meds delivered to your door – and you don’t even need a prescription! Only certified, first class drugs on offer! Buy more and spend less with our great discount system. |
References
- Swanson M, Cook R. Drugs Chemicals and Blood Dyscrasias. Hamilton, IL:Drug Intelligence Publications, 1977:88–9.
- Gull I, Charlton V. Effects of antipyrine on umbilical and regional metabolism in late gestation in the fetal lamb. Am J Obstet Gynecol 1993;168:706–13.
- Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA:Publishing Sciences Group, 1977:287.
- Lewis PJ, Friedman LA. Prophylaxis of neonatal jaundice with maternal antipyrine treatment. Lancet 1979;1:300–2.
- Hawkins DF. Drugs and Pregnancy. Human Teratogenesis and Related Problems. 2nd ed. New York, NY:Churchill Livingstone, 1987:312.
- McNamara PJ, Burgio D, Yoo SD. Pharmacokinetics of acetaminophen, antipyrine, and salicylic acid in the lactating and nursing rabbit, with model predictions of milk to serum concentration ratios and neonatal dose. Toxicol Appl Pharmacol 1991;109:149–60.
Q&A about Antipyrine
i think i am gettin an ear infection, have ear drops for my baby called antipyrine-benzocaine for auralgan, dont have time or money for doctor, will this help me?
That being said, the dosage for children and adults is the same...which is not all that exact. You can basically fill your ear canal with the stuff and put in a cotton ball to keep it in.
The more "official" dosage is 2-4 drops every 4-6 hours, as needed, for pain.
And to answer you last question: yes, it would help take the pain away.
And to be honest with you - MOST ear infections will heal on their own within a week. Antibiotics can speed up this process, but most of the time are unneccessary.
So, it would be reasonable for you to use the antipyrine-benzocaine regularly for the next few days and see if you get better.
If you don't, then you could go see your doctor and see what is going on. Of course, not all ear pain is a simple middle ear infection (otitis media). Sometimes it is an otitis externa (outer ear infection), which could be caused by bacteria or even fungus. Also, it could be "referred pain" from a tooth cavity.
Hope this helps some!
This medication is also used to remove excessive or impacted earwax.
