AMYL NITRITE

Fetal Risk Summary

Amyl nitrite is a rapid-acting, short-duration vasodilator used primarily for the treatment of angina pectoris. Because of the nature of its indication, experience in pregnancy is limited. The Collaborative Perinatal Project recorded 7 1st trimester exposures to amyl nitrite and nitroglycerin plus 8 other patients exposed to other vasodilators (1). From this small group of 15 patients, 4 malformed children were produced, a statistically significant incidence (p<0.02). It was not stated whether amyl nitrite was taken by any of the mothers of the affected infants. Although the data serve as a warning, the number of patients is so small that conclusions as to the relative safety of amyl nitrite in pregnancy cannot be made.

Breast Feeding Summary

No data are available.

Reference