Acitretin

Risk Factor: XM
Class: Vitamins


Contents of this page:

Breast Feeding Summary

No reports describing the use of acitretin during human lactation have been located. The drug is excreted into the milk of lactating rats (1). Vitamin A is excreted into human breast milk and the excretion of acitretin should be expected. Because of the potential for serious adverse reactions, breast feeding while consuming acitretin is not recommended. The plasma elimination half-lives of acitretin and 13-cis-acitretin may be as long as 96 and 157 hours, respectively (1). Because of storage in subcutaneous fat, the actual elimination of these compounds may take much longer. The manufacturer recommends a contraception period of 3 years after acitretin therapy is stopped, but a similar recommendation for breast feeding has not been made.

References

  1. Product information. Soriatane. Roche Laboratories, 2000.
  2. Sturkenboom MCJM, DeJong-Van Den Berg LTW, Van Voorst-Vader PC, Cornel MC, Stricker BHCH, Wesseling H. Inability to detect plasma etretinate and acitretin is a poor predictor of the absence of these teratogens in tissue after stopping acitretin treatment. Br J Clin Pharmacol 1994;38:22935.
  3. De Die-Smulders CEM, Sturkenboom MCJM, Veraart J, Van Katwijk C, Sastrowijoto P, Van Der Linden E. Severe limb defects and craniofacial anomalies in a fetus conceived during acitretin therapy. Teratology 1995;52:2159.
  4. Geiger JM, Baudin M, Saurat JH. Teratogenic risk with etretinate and acitretin treatment. Dermatology 1994;189:10916.
  5. Maradit H, Geiger JM. Potential risk of birth defects after acitretin discontinuation. Dermatology 1999;198:34.
  6. Berbis Ph, Bun H, Geiger JM, Rognin C, Durand A, Serradimigni A, Hartmann D, Privat Y. Acitretin (RO10-1670) and oral contraceptives: interaction study. Arch Dermatol Res 1988;280:3889.
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Questions and Answers

sine i have to take a double dose of acitretin what side affects are moslty likely to kick in.?, i ahve to have a double dose becuase there's something wrong with my liver.

The side affects would be like taking a few more pills of Vit A then normal. Maybe mild head ache and a little blurred vision. If you do have something wrong with your liver, you really shouldn't be taking Acitretin since this medicine can easily make it worse. Also, you should not take a double dose of something just because you missed a dose, that can be very dangerous. Acitretin stays in your system for a couple of days so missing a dose is not the end of the world.

can acitretin kill you.?, since i have something wrong with my liver i have to take acitretin so is it bad or is all of the side affects alright and not very seroous.

Acitretin is a very strong medication used in the treatment psoriasis. Psoriasis is, by the way, a skin condition which causes flaking of skin cells Acitretin is not recommended in pregnancy and in fact has several side effects. One of the side effects is hypoglycaemia, or low blood sugar. This can lead to loss of consciousness or coma Yes, it can kill.



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