Acetylcholine
Risk Factor: C
Class: Autonomics
/ Parasympathomimetics (cholinergics)
Contents of this page:
Fetal Risk Summary
Acetylcholine is used primarily in the eye. No reports of its use in pregnancy have been located. As a quaternary ammonium compound, it is ionized at physiologic pH, and transplacental passage in significant amounts would not be expected.
Breast Feeding Summary
No data are available.
Questions and Answers
Acetylcholine.....?, Just a random question but what would happen if my body had alot of Acetylcholine, alot more then usual? Like would i be more alert, or quicker? or what would happen?
Not unless something is wrong in your system,the acetylcholine release is well regulated so you won't have a lot of it in normal situations. Anyway, supposing you had a lot of it, there will be hyperresponsiveness in your vital functions and there will be excessive smooth muscle contractions.
How would you explain what an acetylcholine inhibitor does, to someone in means they would understand?, Say someone takes a blood test and when it comes back, it turns out that person had been contaminated with organophosphate pesticide. Well, this pesticide is an acetylcholine inhibitor. how would you explain that to this person so they could understand what is happening?
I think what you mean is the organophosphate is an irreversible inhibitor of the cholinesterase enzyme that metabolises acetylcholine, the neurotransmiter. As such it takes about a day or 2 to resynthesize this enzyme. In the meantime they treat the person supportively often with atropine or hyoscine injections to reduce the toxicity of excess acetylcholine
Is acetylcholine just another excitatory neurotransmitter similar to glutamate?, So if acetylcholine binds to its receptor opening the channel that allows positive ions into the neuron, that can lead to the release of any number of different neurotransmitters, like dopamine?
yes ach is present both in the pns and cns, in pns its mainly involved in muscle movements and in the pns its a neurotransmitter, specifically neuromodulator resulting in excitatory actions, similar to glutamate.
How do you produce more acetylcholine?, If your acetylcholine is decreasing to a less than regular amount, what do you need to do to produce more of it?
You might view the following journal article
Apple Juice Inproves Memory By Boosting Acetylcholine Production
Aug 2, 2006, 12:01, Reviewed by: Dr. Venkat Yelamanchili
"The findings of the present study show that consumption of antioxidant-rich foods such as apples and apple juice can help reduce problems associated with memory loss."
How does the Acetylcholine causes dilation of the blood vessels?, Blood vessels does not have any Muscarinic receptors or innervation.
"ENDOTHELIUM-DEPENDENT dilation induced by agonists like acetylcholine is partially resistant to inhibitors of nitric oxide-mediated dilation (15, 18, 22). Acetylcholine also evokes endothelium-dependent smooth muscle hyperpolarization, which is not inhibited by L-arginine analogues, methylene blue or hemoglobin (8, 12, 19). Furthermore, exogenous nitric oxide has little affect on smooth muscle membrane potential (19, 28). Therefore, the hyperpolarizing effect of agonists like acetylcholine has been attributed to an endothelium-derived hyperpolarizing factor (EDHF). "
What role do both dopamine and acetylcholine have when they function as excitatory neurotransmitters?, a) They make the postsynaptic membrane more permeable to K+ ions.
b) They make the presynaptic membrane more permeable to K+ ions.
c) They make the presynaptic membrane more permeable to Na+ ions.
d) They make the postsynaptic membrane more permeable to Na+ ions.
I can't find the answer in my textbook anywhere, anyone know?
D) They make the postsynaptic membrane more permeable to Na+ ions.
How is acetylcholine removed after transmission at the synapse?, I have this question in my excercise science course...anyways, i cant find it in my text book and when googling it...anyone help me?
Answer from a Biology M.sc and specialiged in physiology.
BUT just because I am also a teacher I tell you to be patient and read everything carefully. Please!
I am leading you step by step into knowledge: ( then judge)
1. Acetylcholine is a neurotransmitter chemical present in a cholinergic synapse; ( in short - 'Ach')
2. Helps in the transmission of nerve impulses from a neuron to a neuron;
3.Whereas, a synapse is the conection between two neurons( action potentials are transmitted between at least two neurons across synapses);
4. S0, a cholinergic synapse consists of respectedly ( linewise)------> ( You must have a diagram in book)
Action of the presynaptic neuron---->synaptic knob with Acholine in synaptic vescicle-> presynaptic membrane--> intersynaptic plate or the synaptic cleft -->postsynaptic membrane--> deactivation or removal of Ach. ( see the diagram if You have)
Stages ( step by step)
STEP 1. arrival of a nerve impulses through axon at the end of a presynaptic neuron;
STEP 2. Causing a reflux of Calcium ions and also Acetylocholine to release from vesicle right there; ( 1st synapse part)
STEP 3. Acetylocholine diffuses across the synaptic cleft ( space) to receptors in the post synaptic membrane( 2nd synapse part); Mitohodria provide energy for trasport.
STEP 4. The neurotransmitter( Acetylocholine) binds to receptors on the post synaptic membrane ( 4th synaptic part);
STEP 5. Ion channel open in the membrane causing a influx of sodium ion;
STEP 6. cause geneating of nerve impulse ( sometime not);
LAST STEP -----> YOUR ANSWER
STEP 7. Aetylocholine is finally deactivated by an enzyme called ACETYLCHOLINESSTERASE present in the post synaptic membrane. ( = Ach removed)
Final fate of Acetylcholine: components of Ach is actively reabsorved, back to the synaptic knob recycled and repackaged.
WISH YOU BEST LUCK -Shanki
How does the human brain produce neurotransmitters such as serotonin, dopamine, and acetylcholine?, And what does it need to produce it?
Food they help your body produce these chemicals naturally and contain essential amino acids that are precursors to these chemicals. Foods rich in dairy meat turkey chocolate all boost Trptophan levels. This amino acid is a precursor in the body it get processed to the brain and is used for serotonin production. The sun can also boost serotonin release in the Brain. Exercise caffeine the sun and previous mentioned foods can boost adrenaline and dopamine levels. The sun is essential for the body and vitamin d production but it also stimulates the production of chemicals in the brain
like serotonin and dopamine. I'm sure their are other foods that contain chemicals essential for the body and your brains brain chemistry Your body really effects your brain.
what happen to acetylcholine in the tissues to prevent it from having a prolonged effect?, nor-epinephrine released from, the sympathetic nerves and epinephrine released from the adrenal medulla have numerous cardiovascular and metabolic effects that in total constitue the fight or flight reaction. How do the actions od epinephrine that u have observed contribute to the flight or fight rxn?
it gets degraded by acetylcholinesterase
